RAF Typhoon FGR4s have conducted a mission with French aircraft in a joint strike on an subterranean weapons facility in Syria used by the IS group, according to the UK Ministry of Defence.
The facility, identified by reconnaissance, was thought to be storing arms and explosives, the statement said, and was located in mountains just north of Palmyra in central Syria.
"Our aircraft utilized laser-guided Paveway IV weapons to strike a series of approach shafts providing entry to the depot... initial indications suggest the strike was effective," the MoD said.
There was no indication of any harm to civilians in the operation late on Saturday and each participating jet returned safely, the MoD added.
The Typhoon FGR4s were supported by a Voyager tanker plane.
Daesh - referred to as the so-called Islamic State - imposed militant control over significant areas in Syria and Iraq prior to its 2019 collapse.
"This action demonstrates the UK's leading role, and resolve to stand shoulder to shoulder with allied nations, to eradicate any re-emergence of the terrorist group and their dangerous and violent ideologies in the area," the British Defence Secretary the minister stated.
UK warplanes have carried out overwatch operations over Syrian airspace to "forestall any efforts to regroup" of IS subsequent to its routing at the Baghuz confrontation in 2019, the ministry said.
"I extend gratitude to the personnel of British forces participating in this operation for their expertise and their valour," he said. "They were part of a great many UK service members deployed over Christmas and New Year. This mission, to remove dangerous terrorists who endanger our safety, demonstrates how British military are ready to step up, throughout the year, ensuring Britain's security within its borders and strong abroad."
During December, the US military carried out what it termed a "large-scale strike" against IS targets in Syria, following an ambush resulted in the deaths of two American soldiers and a civilian interpreter in the Palmyra area.
The UN says IS still boasts between 5,000 and 7,000 combatants in Syria and Iraq.
